STMicroelectronics recommends a 2-layer PCB with a thermal pad connected to a large copper area on the bottom layer to dissipate heat efficiently.
Use a heat sink, ensure good airflow, and consider derating the device's current handling capability according to the temperature derating curve in the datasheet.
The maximum allowed voltage on the enable pin (EN) is 6V, exceeding which may cause damage to the device.
Yes, but ensure that the device is properly bypassed and decoupled, and that the PCB layout is optimized for high-frequency operation.
Use a TVS (Transient Voltage Suppressor) diode or a varistor to protect the device from voltage transients and spikes.