The TPS5450DDA can handle input voltages up to 42V, but it's recommended to keep the input voltage below 40V for reliable operation.
The inductor value depends on the output voltage, output current, and switching frequency. A good starting point is to use the inductor value calculation formula provided in the datasheet, and then adjust based on the specific design requirements.
The EN (enable) pin is used to turn the converter on and off. Connect the EN pin to a logic high (e.g., VCC) to enable the converter, and connect it to a logic low (e.g., GND) to disable it.
Ensure good thermal design, including a heat sink if necessary, and follow the thermal design guidelines in the datasheet. Monitor the device temperature and adjust the design as needed to keep the junction temperature below 125°C.
Follow the recommended PCB layout guidelines in the datasheet, including keeping the high-current paths short and wide, and using a solid ground plane to reduce noise and improve thermal performance.