A good PCB layout for the TPA3100D2PHPR involves keeping the input and output traces short and away from each other, using a solid ground plane, and placing decoupling capacitors close to the device. TI provides a recommended layout in the datasheet and application notes.
The gain setting depends on the input signal level, desired output power, and system impedance. TI provides a gain setting table in the datasheet, and you can also use the TI Audio Amplifier Gain Calculator tool to help select the optimal gain setting.
The maximum power dissipation of the TPA3100D2PHPR is dependent on the ambient temperature and the thermal resistance of the PCB. TI provides a power dissipation calculation formula in the datasheet, and you can also use the TI Power Dissipation Calculator tool to estimate the maximum power dissipation.
To protect the TPA3100D2PHPR from overheating, ensure good thermal conduction by using a heat sink or a thermally conductive PCB, keep the device away from heat sources, and implement thermal monitoring and shutdown circuits if necessary.
The recommended input coupling capacitor value depends on the input signal frequency and impedance. A general rule of thumb is to use a capacitor with a value of 1-10 μF, but TI recommends consulting the datasheet and application notes for specific guidance.