A good thermal design should include a solid ground plane, thermal vias under the device, and a heat sink if possible. Refer to the TI application note 'TPA2016D2 Thermal Design Considerations' for more information.
To ensure stability, follow the recommended component values and PCB layout guidelines in the datasheet. Additionally, use a low-ESR capacitor for the bootstrap capacitor (C2) and keep the input and output traces short and symmetrical.
The maximum power dissipation of the TPA2016D2 is dependent on the ambient temperature and the thermal resistance of the PCB. Refer to the datasheet's thermal characteristics table to determine the maximum power dissipation for your specific application.
While the TPA2016D2 can operate with a lower voltage power supply, the output power and efficiency will be reduced. The minimum recommended voltage is 8V, but this may not provide sufficient headroom for some applications.
Use a voltage regulator or a transient voltage suppressor (TVS) to protect the amplifier from overvoltage. For ESD protection, use a TVS or a dedicated ESD protection device, such as the TI TPD1E10B06.