The maximum operating frequency of the SN74LVC8T245DGVR is 100 MHz.
Yes, the SN74LVC8T245DGVR is compatible with 3.3V systems and can operate with a supply voltage range of 1.65V to 3.6V.
To ensure signal integrity, use a low-impedance PCB design, keep signal traces short, and use termination resistors if necessary. Also, follow the recommended layout guidelines in the datasheet.
The SN74LVC8T245DGVR is rated for operation up to 85°C, but it can be used in high-temperature environments up to 125°C with some derating. Consult the datasheet for specific derating guidelines.
The SN74LVC8T245DGVR has built-in ESD protection, but it's still important to follow proper ESD handling procedures during assembly and testing. Use an ESD wrist strap or mat, and handle the device by the body or pins, not the leads.