The maximum frequency of operation for the SN74HC245DW is 50 MHz.
To ensure signal integrity, use a low-impedance output driver, minimize trace lengths, and use a ground plane to reduce noise and electromagnetic interference (EMI).
Yes, the SN74HC245DW is compatible with 5V systems, but ensure that the input voltage (VCC) is within the recommended operating range of 2V to 6V.
To avoid latch-up, ensure that the power supply voltage (VCC) is applied before the input signals, and that the input signals are stable before the output enable (OE) is asserted.
The SN74HC245DW can sink or source up to 25 mA per output pin.