Texas Instruments recommends a 4-layer PCB with a solid ground plane, and to keep the analog and digital grounds separate. Additionally, use a star-configuration for the power supply and keep the decoupling capacitors close to the device.
To minimize power consumption, use the lowest possible clock frequency, disable unused features, and use the power-down mode when not in use. Also, consider using a low-dropout regulator (LDO) to reduce power consumption.
The maximum allowed capacitance for the output filter capacitors is 10uF. Exceeding this value may cause instability in the device.
The SN65220DBVR is rated for operation up to 125°C. However, it's essential to ensure proper thermal management and consider the device's thermal resistance to avoid overheating.
Use an oscilloscope to monitor the output voltage and current. Check for proper PCB layout, decoupling, and filtering. Verify the input voltage and clock frequency meet the recommended specifications. Consult the datasheet and application notes for troubleshooting guidelines.