The PCA9544AD can support I2C bus frequencies up to 400 kHz.
Yes, the PCA9544AD can be used to switch between multiple I2C buses with different voltage levels, as long as the voltage levels are within the specified range of 1.8 V to 5.5 V.
To ensure that the PCA9544AD is properly powered down, the EN pin should be pulled low, and the VCC pin should be connected to a power source that can be switched off.
Yes, the PCA9544AD can be used in applications that require hot-swapping of I2C devices, as it has built-in protection against voltage and current surges.
The PCA9544AD can support up to 4 I2C buses, each with a maximum of 8 devices, for a total of 32 devices.