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The PCA9539PW/Q900,118 can support I2C bus frequencies up to 400 kHz.
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The PCA9539PW/Q900,118 can handle up to 16 external interrupts.
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The PCA9539PW/Q900,118 can sink or source up to 25 mA per output.
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Yes, the PCA9539PW/Q900,118 is 5V tolerant, but it operates at a maximum voltage of 3.6V. It can be used in a 5V system with proper level shifting.
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The PCA9539PW/Q900,118 has built-in overcurrent protection, which limits the output current to prevent damage to the device.