Broadcom recommends a 4-layer PCB with a solid ground plane, and thermal vias under the package to dissipate heat. A thermal pad on the bottom of the package should be connected to a thermal plane on the PCB.
To ensure reliable operation, follow the recommended operating conditions, including voltage, current, and temperature ranges. Also, consider using thermal protection and over-temperature shutdown mechanisms in your design.
The HLMT-QH00-T0021 has built-in ESD protection, but it's still important to follow standard ESD handling procedures, such as using an ESD wrist strap, mat, or workstation, and storing the devices in anti-static packaging.
The HLMT-QH00-T0021 is a commercial-grade device, but it can be used in high-reliability or safety-critical applications with proper design, testing, and validation. Consult with Broadcom's application engineers and follow relevant industry standards and guidelines.
The HLMT-QH00-T0021 is not specifically designed for radiation-hardened applications, but it has some level of radiation tolerance. Consult with Broadcom's application engineers for more information on latch-up characteristics and radiation tolerance.