The maximum frequency of operation for the CD74HC245M is 50 MHz.
Yes, the CD74HC245M is compatible with 5V systems, but it's recommended to use a voltage regulator to ensure a stable 5V supply.
The enable pins (1E and 2E) are active-low, meaning they need to be pulled low to enable the corresponding bus. You can tie them to GND or use a logic signal to control them.
The propagation delay of the CD74HC245M is typically around 10-15 ns, but it can vary depending on the operating conditions and load capacitance.
Yes, the CD74HC245M can be used as a level shifter, but it's not recommended as it's not designed for that purpose. Instead, use a dedicated level shifter IC for better performance and reliability.