The maximum frequency of operation for the CD74HC243M96 is 25 MHz.
To ensure signal integrity, use a low-impedance output driver, minimize trace lengths, and use a ground plane to reduce noise and electromagnetic interference (EMI).
The recommended power-on sequence is to apply VCC before applying any input signals, and to ensure that all inputs are at a valid logic level before applying VCC.
Use a heat sink or thermal pad to dissipate heat, and ensure good airflow around the device. The maximum junction temperature is 150°C.
The CD74HC243M96 has human-body model (HBM) ESD protection of 2 kV and charged-device model (CDM) ESD protection of 1 kV.