The maximum frequency of operation for the CD74HC221NSR is 25 MHz.
Yes, the CD74HC221NSR is compatible with 5V systems, but it's recommended to use a voltage regulator to ensure a stable 5V supply.
It's recommended to power up the VCC pin first, followed by the input signals, and power down the input signals before the VCC pin to prevent latch-up.
The recommended operating temperature range for the CD74HC221NSR is -40°C to 85°C.
The CD74HC221NSR is a commercial-grade device and may not meet the requirements for high-reliability or aerospace applications. Consider using a radiation-hardened or high-reliability version of the device for such applications.