The maximum operating frequency of the 74HCT245N is 50 MHz, but it can vary depending on the capacitive load and the output current.
Yes, the 74HCT245N can be used as a level shifter between 3.3V and 5V logic levels, but ensure that the input voltage is within the recommended range of 2V to VCC + 0.5V.
When not using the enable pins (1E and 2E), tie them to VCC or GND, depending on the desired state. Leaving them floating can cause unpredictable behavior.
The 74HCT245N can sink or source up to 20mA per output pin, but it's recommended to limit the current to 10mA or less to ensure reliable operation.
The 74HCT245N is rated for operation up to 125°C, but it's recommended to derate the device for high-temperature applications to ensure reliable operation.